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Peter Attia, MD is a highly respected expert in preventive medicine, focused on the crucial subject of longevity and cardiovascular health. He's also the author of the NY Times best selling book Outlive - which I highly recommend if you have not read it already. Peter's philosophy transcends the conventional goal of merely extending lifespan; it's about enriching the quality of every year, ensuring that each stage of life is lived with optimal health and vitality.

In this episode, we discuss:

• (00:07:36) Defining cardiovascular disease
• (00:09:43) Coronary plaque and fatality risk
• (00:11:09) What is cholesterol?
• (00:13:34) How ApoB predicts heart disease
• (00:21:34) Factors elevating ApoB
• (00:25:24) ApoB reference range explained
• (00:27:23) Does high ApoB cause cardiovascular disease
• (00:37:01) ApoB thresholds for ASCVD prevention
• (00:40:27) Dietary factors raising ApoB
• (00:39:33) Genetics of ApoB and LDL
• (00:53:24) Does low LDL increase cancer?
• (00:56:19) Cholesterol-lowering drugs
• (00:59:59) Statins, uses, and side effects
• (01:03:12) Are statins toxic to mitochondria?
• (01:09:56) Ubiquinol for statin-induced muscle soreness
• (01:11:09) How to train in zone 2
• (01:17:09) Statins and neurodegenerative disease risk
• (01:21:54) Cholesterol synthesis in the brain (desmosterol role)
• (01:25:58) Statin alternatives \u2013 pros and cons
• (01:27:30) Ezetimibe
• (01:31:01) Bempedoic acid
• (01:36:49) Berberine for CVD Risk Reduction?
• (01:39:36) Muscle as a glucose sink
• (01:45:58) Chronic glucose toxicity and vascular impact
• (01:51:38) Hemoglobin A1C Levels and Mortality Data
• (01:55:35) 80/20 Zone 2/VO2 Max Training Protocol
• (02:02:12) Insights from VO2 max testing data
• (02:12:17) How obesity increases cancer risk
• (02:15:03) Cancer screening benefits and risks
• (02:20:47) Dr. Attia's recommended cancer screening age
• (02:28:54) Liquid biopsies for detecting cancer
• (02:34:48) CT scans, mammograms and radiation concerns
• (02:40:32) Menopause \u2013 hormonal shifts and health effects
• (02:45:13) Hormone replacement therapy (HRT)
• (02:58:57) Perimenopause diagnosis with hormone levels
• (03:02:04) HRT's impact on dementia, cancer, and heart disease risk
• (03:04:49) Estrogen's role in bone density
• (03:07:42) Vitamin D
• (03:16:24) Testosterone replacement for women's sexual function
• (03:18:47) HRT safety 10 years post-menopause
• (03:23:05) Treating low testosterone in men
• (03:29:53) TRT side effects and risks
• (03:32:33) Ways to reduce blood pressure
• (03:39:33) How to measure blood pressure
• (03:45:30) Peter's longevity optimization routines

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