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Heterochromatin plays a pivotal role in organizing our genome in the nucleus and separating active from inactive genomic regions. In this Podcast Episode our Guest Gary Karpen from UC Berkeley sits down with our Host Stefan Dillinger to talk about the regulation of this chromatin structure and how DNA repair mechanisms function in this densely packed nuclear compartment. Furthermore, they also discuss how phase separation might be an important part in how heterochromatin domains are formed.\nReferences \nJamy C. Peng, Gary H. Karpen (2009) Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation (PLoS Genetics) DOI: 10.1371/journal.pgen.1000435\nPeter V. Kharchenko, Artyom A. Alekseyenko, \u2026 Peter J. Park (2011) Comprehensive analysis of the chromatin landscape in Drosophila melanogaster (Nature) DOI: 10.1038/nature09725\nAniek Janssen, Serafin U. Colmenares, \u2026 Gary H. Karpen (2019) Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A (Genes & Development) DOI: 10.1101/gad.317537.118\xa0\nAmy R. Strom, Alexander V. Emelyanov, \u2026 Gary H. Karpen (2017) Phase separation drives heterochromatin domain formation (Nature) DOI: 10.1038/nature22989\nContact\nhttps://twitter.com/activemotif \nhttps://twitter.com/epigenetics_pod \nhttps://www.linkedin.com/company-beta/35651/ \nhttps://www.facebook.com/ActiveMotifInc/ \nhttps://activemotif.com/blog \npodcast@activemotif.com