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In this episode of the Epigenetics Podcast, we caught up with Akis Papantonis from the University Medical Center G\xf6ttingen to talk about his work on genome organisation mediated by RNA Polymerase II.\nThe research of the Papantonis Laboratory focuses on investigating how environmental signalling stimuli are integrated by chromatin to control homeostatic to deregulated functional transitions. In more detail, the team is interested in how dynamic higher-order regulatory networks are influenced by the underlying linear DNA fiber. The ultimate goal of the laboratory is to understand general rules governing transcriptional and chromatin homeostasis and finally, how those rules might affect development, ageing or malignancies.\n\xa0\nReferences\n\nLarkin, J. D., Cook, P. R., & Papantonis, A. (2012). Dynamic reconfiguration of long human genes during one transcription cycle. Molecular and cellular biology, 32(14), 2738\u20132747. https://doi.org/10.1128/MCB.00179-12\n\n\nDiermeier, S., Kolovos, P., Heizinger, L., Schwartz, U., Georgomanolis, T., Zirkel, A., Wedemann, G., Grosveld, F., Knoch, T. A., Merkl, R., Cook, P. R., L\xe4ngst, G., & Papantonis, A. (2014). TNF\u03b1 signalling primes chromatin for NF-\u03baB binding and induces rapid and widespread nucleosome repositioning. Genome biology, 15(12), 536. https://doi.org/10.1186/s13059-014-0536-6\n\n\nSofiadis, K., Josipovic, N., Nikolic, M., Kargapolova, Y., \xdcbelmesser, N., Varamogianni-Mamatsi, V., Zirkel, A., Papadionysiou, I., Loughran, G., Keane, J., Michel, A., Gusmao, E. G., Becker, C., Altm\xfcller, J., Georgomanolis, T., Mizi, A., & Papantonis, A. (2021). HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence. Molecular systems biology, 17(6), e9760. https://doi.org/10.15252/msb.20209760\n\n\nEnhancer-promoter contact formation requires RNAPII and antagonizes loop extrusion. Shu Zhang, Nadine \xdcbelmesser, Mariano Barbieri, Argyris Papantonis. bioRxiv 2022.07.04.498738; doi: https://doi.org/10.1101/2022.07.04.498738\n\xa0\n\nRelated Episodes\n\nChromatin Organization During Development and Disease (Marieke Oudelaar)\n\n\nBiophysical Modeling of 3-D Genome Organization (Leonid Mirny)\n\n\nHi-C and Three-Dimensional Genome Sequencing (Erez Lieberman Aiden)\n\n\xa0\nContact\n\nEpigenetics Podcast on Twitter\n\n\nEpigenetics Podcast on Instagram\n\n\nEpigenetics Podcast on Mastodon\n\n\nActive Motif on Twitter\n\n\nActive Motif on LinkedIn\n\n\nEmail: podcast@activemotif.com