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This episode from Web3 with a16z Crypto, is all about innovation on a global scale, exploring both ecosystem and individual talent levels. We examine what works and what doesn\u2019t, how certain regions evolve into startup hubs and economic powerhouses, and what constitutes entrepreneurial talent. We also discuss the nature of ambition, the journey to finding one\u2019s path, and broader mindsets for navigating risk, reward, and dynamism across various regions, with a particular focus on London and Europe.\n\nJoining us is Matt Clifford, who played a pivotal role in the London entrepreneurial and tech ecosystem since 2011, is the Chair of Entrepreneur First and the UK\u2019s Advanced Research and Invention Agency (ARIA). Before this episode was recorded, Matt served as the Prime Minister\u2019s representative for the AI Safety Summit at Bletchley Park. Recently, he was appointed by the UK Secretary of Science to deliver an \u201cAI Opportunities Action Plan\u201d to the UK government.\n\nThis episode was recorded live from Andreessen Horowitz\u2019s first international office in London. For more on our efforts and additional content, visit a16zcrypto.com/uk.