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139 episodes

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DPP9 directly sequesters the NLRP1 C-terminus to repress inflammasome activation

Published: Aug. 14, 2020, 10:02 p.m.
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Listed in: Science

New models to study plasma cells in mouse based on the restriction of IgJ expression to antibody secreting cells.

Published: Aug. 14, 2020, 4:03 p.m.
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An easy and reliable whole blood freezing method for flow cytometry immuno- phenotyping and functional analyses

Published: Aug. 14, 2020, 10:02 a.m.
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Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

Published: Aug. 14, 2020, 10:02 a.m.
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Sero-Prevalence and Associated Risk Factors of Bovine Brucellosis in Sendafa, Oromia Special Zone Surrounding Addis Ababa, Ethiopia

Published: Aug. 13, 2020, 7:01 a.m.
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IL-27 enhances the lymphocyte mediated innate resistance to primary hookworm infection in the lungs

Published: Aug. 12, 2020, 6:02 a.m.
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A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

Published: Aug. 12, 2020, 5:02 a.m.
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The retinoic acid receptor drives neuroinflammation and fine tunes the homeostasis of interleukin-17-producing T cells

Published: Aug. 12, 2020, 5:02 a.m.
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Disparate regulation of imd drives sex differences in infection tolerance in Drosophila melanogaster

Published: Aug. 12, 2020, 5:02 a.m.
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Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

Published: Aug. 12, 2020, 4:02 a.m.
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Efficacy of Targeting SARS-CoV-2 by CAR-NK Cells

Published: Aug. 12, 2020, 4:01 a.m.
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Cytokine priming of naive CD8+ T lymphocytes modulates chromatin accessibility that partially overlaps with changes induced by antigen simulation

Published: Aug. 12, 2020, 2:07 a.m.
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Human neonatal B cell immunity differs from the adult version by conserved Ig repertoires and rapid, but transient response dynamics

Published: Aug. 12, 2020, 2:06 a.m.
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The identity of human tissue-emigrant CD8+ T cells

Published: Aug. 11, 2020, 9:01 p.m.
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Interruption in POSTN-ITGAV axis affects lympho-hematopoiesis in mouse spleen

Published: Aug. 11, 2020, 9:01 p.m.
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The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

Published: Aug. 11, 2020, 5:01 a.m.
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Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

Published: Aug. 11, 2020, 2:01 a.m.
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Opposing activities of IFITM proteins in SARS-CoV-2 infection

Published: Aug. 11, 2020, 2:01 a.m.
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CD40 provides immune privilege to the bone marrow hematopoietic niche

Published: Aug. 10, 2020, 10:02 p.m.
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SPARC regulation of PMN clearance protects from pristane induced lupus and rheumatoid arthritis

Published: Aug. 10, 2020, 10:02 p.m.
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Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing

Published: Aug. 10, 2020, 10:02 p.m.
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A comparison of non-magnetic and magnetic beads for measuring IgG antibodies against P. vivax antigens in a multiplexed bead-based assay using Luminex(R) technology (Bio-Plex(R)200 or MAGPIX(R))

Published: Aug. 10, 2020, 12:01 p.m.
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Antigen-Specific T Cell Recall Assay To Screen Drugs For Off-Target Effects

Published: Aug. 10, 2020, 12:01 p.m.
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A Broadly Neutralizing Macaque Monoclonal Antibody Against the HIV-1 V3-Glycan Patch

Published: Aug. 10, 2020, 5:02 a.m.
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Comparative analyses of SARS-CoV-2 binding (IgG, IgM, IgA) and neutralizing antibodies from human serum samples

Published: Aug. 10, 2020, 5:02 a.m.
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DCL-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

Published: Aug. 10, 2020, 5:01 a.m.
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SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease

Published: Aug. 10, 2020, 5:01 a.m.
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Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

Published: Aug. 10, 2020, 5:01 a.m.
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Bmp8a Is a Novel Player in Regulation of Antiviral Immunity

Published: Aug. 10, 2020, 5:01 a.m.
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Reduced placental transfer of antibodies against microbial and vaccine antigens in HIV-infected women in Mozambique

Published: Aug. 7, 2020, 3:01 p.m.
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Human Microbial Transplant Restores T Cell Cytotoxicity and Anti-Tumor Response to PD-L1 Blockade in Gnotobiotic Mice

Published: Aug. 7, 2020, 6:01 a.m.
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Effect of oxidized β-carotene-oxygen copolymer compounds on health and performance of pre- and post-weaned pigs

Published: Aug. 7, 2020, 3:02 a.m.
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mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2

Published: Aug. 7, 2020, 2:02 a.m.
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An Epitope-based Malaria Vaccine Targeting the Junctional Domain of Circumsporozoite Protein

Published: Aug. 7, 2020, 12:07 a.m.
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Macrophages promote endothelial-to-mesenchymal transition via MT1-MMPTGFβ after myocardial infarction

Published: Aug. 7, 2020, 12:07 a.m.
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Innovation in NLR and TLR sensing drives the MHC-II free Atlantic cod immune system.

Published: Aug. 7, 2020, 12:07 a.m.
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Predicted Cellular Immunity Population Coverage Gaps for SARS-CoV-2 Subunit Vaccines and their Augmentation by Compact Joint Sets

Published: Aug. 6, 2020, 11:02 p.m.
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Consensus transcriptional states describe human mononuclear phagocyte diversity in the lung across health and disease

Published: Aug. 6, 2020, 8:03 a.m.
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Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection

Published: Aug. 6, 2020, 7:03 a.m.
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DDX50 is a viral restriction factor thay enhances TRIF-dependent IRF3 activation

Published: Aug. 6, 2020, 7:03 a.m.
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IL-4 receptor targeting as an effective immunotherapy against triple-negative breast cancer

Published: Aug. 6, 2020, 5:04 a.m.
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IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

Published: Aug. 6, 2020, 2:03 a.m.
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Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

Published: Aug. 6, 2020, 1:03 a.m.
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Capturing and Recreating Diverse Antibody Repertoires as Multivalent Recombinant Polyclonal Antibody Drugs

Published: Aug. 6, 2020, 1:03 a.m.
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Immune gene expression covaries with gut microbiome composition in stickleback

Published: Aug. 5, 2020, 11:03 p.m.
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Rapid GMP-compliant expansion of SARS-CoV-2-specific T cells from convalescent donors for use as an allogeneic cell therapy for COVID-19

Published: Aug. 5, 2020, 11:02 p.m.
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Immunosuppressive role of PGE2 during human tuberculosis

Published: Aug. 5, 2020, 10:03 p.m.
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Proteogenomic analysis unveils the HLA Class I presented immunopeptidome in melanoma and EGFR mutant lung adenocarcinoma

Published: Aug. 5, 2020, 9:03 p.m.
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Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice

Published: Aug. 5, 2020, 5:02 p.m.
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Antigen-specific induction of CD4+CD8αα+ intraepithelial T lymphocytes byBacteroidetes species

Published: Aug. 5, 2020, 5:02 p.m.
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Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

Published: Aug. 5, 2020, 7:02 a.m.
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PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

Published: Aug. 5, 2020, 6:03 a.m.
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Post-Transcriptional Regulation of Antiviral Gene Expression by N6-Methyladenosine

Published: Aug. 5, 2020, 6:03 a.m.
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The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

Published: Aug. 5, 2020, 5:01 a.m.
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Nasal commensal, Staphylococcus epidermidis shapes the mucosal environment to prevent influenza virus invasion through Serpine1 induction

Published: Aug. 4, 2020, 11:02 p.m.
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Identification of a prostaglandin E2 receptor that regulates mosquito oenocytoid immune cell function in limiting bacteria and parasite infection

Published: Aug. 4, 2020, 11:02 p.m.
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Intestinal infection results in impaired lung innate immunity to secondary respiratory infection.

Published: Aug. 4, 2020, 9:01 p.m.
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The human liver microenvironment shapes the homing and function of CD4+ T-cell populations

Published: Aug. 4, 2020, 7:06 p.m.
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Inflammasome- and gasdermin D-independent IL-1β production mobilizes neutrophils to inhibit antitumor immunity

Published: Aug. 4, 2020, 6:01 a.m.
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Interaction of clinical-stage antibodies with heme predicts physiochemical and functional liabilities relevant for developability

Published: Aug. 4, 2020, 5:02 a.m.
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Lymphopenia-induced T cell proliferation is a hallmark of severe COVID-19

Published: Aug. 4, 2020, 4:01 a.m.
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A distinct innate immune signature marks progression from mild to severe COVID-19

Published: Aug. 4, 2020, 4:01 a.m.
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A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

Published: Aug. 4, 2020, 4:01 a.m.
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Peritoneal macrophage phenotype correlates with pain scores in women with suspected endometriosis

Published: Aug. 3, 2020, 9:02 p.m.
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Functional immune mapping with deep-learning enabled phenomics applied to immunomodulatory and COVID-19 drug discovery

Published: Aug. 3, 2020, 5:01 a.m.
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Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation

Published: Aug. 2, 2020, 1:01 p.m.
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CD20 as a gatekeeper of the resting stage of human B cells

Published: July 31, 2020, 10:28 p.m.
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Disordered peptides impair neutrophil bacterial clearance and enhance tissue damage in septic patients

Published: July 31, 2020, 5:02 a.m.
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Expression of Tim-3 drives naive Treg to an effector-like state with enhanced suppressive activity

Published: July 31, 2020, 5:02 a.m.
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Transcriptional Atlas of Ileal-Anal Pouch Immune Cells from Ulcerative Colitis Patients

Published: July 31, 2020, 4:02 a.m.
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Validation and Application of a Bench Top Cell Sorter in a BSL-3 Containment Setting

Published: July 31, 2020, 3:02 a.m.
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Rbx1 Cullin-Ring ligase E3 and Ube2m neddylation E2 differentially governs the fitness of Treg cells

Published: July 31, 2020, 2:03 a.m.
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SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses

Published: July 31, 2020, 1:02 a.m.
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Biochemical Patterns of Antibody Polyreactivity Revealed Through a Bioinformatics-Based Analysis of CDR Loops

Published: July 30, 2020, 11:02 p.m.
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E-cigarettes compromise the gut barrier and trigger gut inflammation

Published: July 30, 2020, 6:02 p.m.
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Mapping the landscape of chromatin dynamics during naïve CD4+ T-cell activation.

Published: July 30, 2020, 6:02 p.m.
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Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

Published: July 30, 2020, 10:03 a.m.
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NK cells integrate signals over large areas when building immune synapses but require local stimuli for degranulation

Published: July 30, 2020, 9:03 a.m.
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How do extracellular membrane-associated proteins stand erect and signal?

Published: July 30, 2020, 9:03 a.m.
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Regulatory T cell activation triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses

Published: July 30, 2020, 9:03 a.m.
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A Multi-Phenotype System to Discover Therapies for Age-Related Dysregulation of the Immune Response to Viral Infections

Published: July 30, 2020, 6:02 a.m.
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Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

Published: July 30, 2020, 5:02 a.m.
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Circulating Mitochondrial DNA is an Early Indicator of Severe Illness and Mortality from COVID-19

Published: July 30, 2020, 5:02 a.m.
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Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2

Published: July 30, 2020, 5:02 a.m.
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Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain.

Published: July 30, 2020, 2:01 a.m.
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Immuno-informatics Design of a Multimeric Epitope Peptide Based Vaccine Targeting SARS-CoV-2 Spike Glycoprotein

Published: July 30, 2020, 1:01 a.m.
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A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses

Published: July 30, 2020, 12:01 a.m.
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No SARS-CoV-2 cross-neutralization by intravenous immunoglobulins produced from plasma collected before the 2020 pandemic

Published: July 30, 2020, 12:01 a.m.
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Human thymopoiesis selects unconventional CD8+ αβ T cells that respond to multiple viruses.

Published: July 29, 2020, 6:01 p.m.
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Enhanced BCR signalling inflicts early plasmablast and germinal centre B cell death

Published: July 29, 2020, 6:02 a.m.
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A test of the Baldwin Effect: Differences in both constitutive expression and inducible responses to parasites underlie variation in host response to a parasite

Published: July 29, 2020, 6:02 a.m.
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Identification and characterization of CD4+ T cell epitopes after Shingrix vaccination.

Published: July 29, 2020, 6:02 a.m.
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Intradermal-delivered DNA vaccine provides anamnestic protection in a rhesus macaque SARS-CoV-2 challenge model

Published: July 29, 2020, 5:01 a.m.
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Regulation of specific cell clusters in TCR-T cells responding to differential expression of tumor PD-L1

Published: July 29, 2020, 2:04 a.m.
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Digital spatial profiling of coronary plaques from persons living with HIV reveals high levels of STING and CD163 in macrophage enriched regions

Published: July 29, 2020, 1:06 a.m.
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Models of SIV rebound after treatment interruption that involve multiple reactivation events

Published: July 29, 2020, 1:05 a.m.
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Mass cytometry analysis of the NK cell receptor-ligand repertoire reveals unique differences between dengue-infected children and adults

Published: July 29, 2020, 12:02 a.m.
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NBS1-CtIP-Mediated DNA End Resection Regulates cGAS Binding to Micronuclei

Published: July 28, 2020, 5:19 p.m.
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Modulation of the mTOR pathway plays a central role in dendritic cell functions after Echinococcus granulosus antigen recognition.

Published: July 28, 2020, 7:01 a.m.
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Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

Published: July 28, 2020, 1:01 a.m.
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Antibodies that potently inhibit or enhance SARS-CoV-2 spike protein-ACE2 interaction isolated from synthetic single-chain antibody libraries

Published: July 28, 2020, 12:02 a.m.
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A Conserved TCRβ signature dominates a highly polyclonal T-cell expansion during the acute phase of a murine malaria infection

Published: July 27, 2020, 7:01 a.m.
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) Protein Inhibits Type I and III Interferon Production by Targeting RIG-IMDA-5 Signaling

Published: July 27, 2020, 5:01 a.m.
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CoVaccine HT™ adjuvant potentiates robust immune responses to recombinant SARS-CoV-2 Spike S1 immunisation

Published: July 26, 2020, 7:58 p.m.
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Identifying hidden drivers of heterogeneous inflammatory diseases

Published: July 26, 2020, 7:58 p.m.
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Microtiter plate-based antibody-competition assay to determine binding affinities and plasmablood stability of CXCR4 ligands

Published: July 26, 2020, 7:58 p.m.
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COVID-19 and Rheumatoid Arthritis share myeloid pathogenic and resolving pathways

Published: July 26, 2020, 7:57 p.m.
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The Role of IgG Subclass in Antibody-Mediated Protection against Carbapenem-Resistant Klebsiella pneumoniae

Published: July 25, 2020, 7:58 p.m.
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High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2

Published: July 25, 2020, 7:58 p.m.
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Single-cell classification using learned cell phenotypes

Published: July 24, 2020, 7:55 p.m.
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Single-cell transcriptome analysis of the immunosuppressive effect of differential expression of tumor PD-L1 on responding TCR-T cells

Published: July 24, 2020, 7:55 p.m.
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NF-kappa-B activation unveils the presence of inflammatory hotspots in human gut xenografts

Published: July 24, 2020, 7:55 p.m.
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Single-cell landscape of immunological responses in COVID-19 patients

Published: July 24, 2020, 7:55 p.m.
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Adopting STING agonist cyclic dinucleotides as a potential adjuvant for SARS-CoV-2 vaccine

Published: July 24, 2020, 7:55 p.m.
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Requirement of the antimicrobial peptide CRAMP for macrophages to eliminate phagocytosed E. coli through an autophagy pathway

Published: July 24, 2020, 7:55 p.m.
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Activating NK- receptors, homing selectins and inhibitory Siglecs recognize EBOLA-GP and HPV-L1NK

Published: July 24, 2020, 7:55 p.m.
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Transcriptional response modules characterise IL-1 and IL-6 activity in COVID-19

Published: July 23, 2020, 7:56 p.m.
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Use of IL-6-elafin genetically modified regulatory macrophages as an immunotherapeutic against acute bacterial infection in the lung

Published: July 23, 2020, 7:56 p.m.
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SARS-CoV-2-induced humoral immunity through B cell epitope analysis and neutralizing activity in COVID-19 infected individuals in Japan

Published: July 23, 2020, 7:55 p.m.
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Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2

Published: July 23, 2020, 7:55 p.m.
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A Systematic Review and Meta-analysis of the Protective Effect of FMDV VP1 on Animals

Published: July 23, 2020, 7:55 p.m.
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