Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.14.339689v1?rss=1 Authors: Abitogun, F. M., Srivastava, R., Sharma, S., Komarysta, V., Akurut, E., Munir, N., Macalalad, L., Ojo-Rowland, O., Owolabi, O., Giwa, A., Debnath, S. Abstract: The COVID19 pandemic has resulted in 1,092,342 deaths as of 14th October 2020, indicating the urgent need for a vaccine. This study highlights novel protein sequences generated by shot gun sequencing protocols that could serve as potential antigens in the development of novel subunit vaccines and through a stringent inclusion criterion, we characterized these protein sequences and predicted their 3D structures. We found distinctly antigenic sequences from the SARS-CoV-2 that have led to identification of 4 proteins that demonstrate an advantageous binding with Human leukocyte antigen-1 molecules. Results show how previously unexplored proteins may serve as better candidates for subunit vaccine development due to their high stability and immunogenicity, reinforce by their HLA-1 binding propensities and low global binding energies. This study thus takes a unique approach towards furthering the development of vaccines by employing multiple consensus strategies involved in immuno-informatics technique. Copy rights belong to original authors. Visit the link for more info