Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.10.244632v1?rss=1 Authors: Aktas, E. Abstract: There are some mutations are known related to SARS-CoV-2. Together with these mutations known, we tried to show other newly mutations regionally. According to our results which 4326 whole sequences are used, we found that some mutations occur only in a certain region, while some other mutations are found in each regions. Especially in Asia, more than one mutation (three different mutations are found in QLA46612 isolated from South Korea) was seen in the same sequence. Although we detected a huge number of mutations (we found more than seventy in Asia) by regions, some of them were predicted that damage spike's protein structure by using bioinformatic tools. The predicted results are G75V (isolated from North America), T95I (isolated from South Korea), G143V (isolated from North America), M177I (isolated Asia), L293M (isolated from Asia), P295H (isolated from Asia), T393P (isolated from Europe), P507S (isolated from Asia), D614G (isolated from all regions) respectively. Also, in this study, we tried to show how possible binding sites of ligands change if the spike protein structure is damaged and whether more than one mutation affects ligand binding was estimated using bioinformatics tools. Interestingly, mutations that predicted to damage the structure do not affect ligand binding sites, whereas ligands' binding sites were affected in those with multiple mutations. Focusing on mutations may opens up the window to exploit new future therapeutic targets. Copy rights belong to original authors. Visit the link for more info