Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA
Transformation of murine thymocytes by\nradiation leukemia virus is associated with reduced expression\nof the class I antigens encoded in the major histocompatibility\ncomplex (MHC) and increased methylation and altered restriction\nenzyme patterns of MHC DNA. These changes may play\na role in host susceptibility to virus-induced leukemogenesis\nand accord with the notion that viral genomes play a regulatory\nfunction when they integrate adjacent to histocompatibiity\ngenes.