Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA
b'Transformation of murine thymocytes by\\nradiation leukemia virus is associated with reduced expression\\nof the class I antigens encoded in the major histocompatibility\\ncomplex (MHC) and increased methylation and altered restriction\\nenzyme patterns of MHC DNA. These changes may play\\na role in host susceptibility to virus-induced leukemogenesis\\nand accord with the notion that viral genomes play a regulatory\\nfunction when they integrate adjacent to histocompatibiity\\ngenes.'