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b'Apkopojot Latvijas iedz\\u012bvot\\u0101ju genoma inform\\u0101ciju, p\\u0113tnieki atkl\\u0101ju\\u0161i interesantus faktus par latvie\\u0161iem un lietuvie\\u0161iem, piem\\u0113ram, mednieku-v\\u0101c\\u0113ju g\\u0113na kl\\u0101tb\\u016btni, kas ir retums m\\u016bsdienu Eiropas iedz\\u012bvot\\u0101ju kopien\\u0101. K\\u0101p\\u0113c nepiecie\\u0161ams apzin\\u0101t iedz\\u012bvot\\u0101ju genomu un ko tas dos medic\\u012bnai un p\\u0113tniec\\u012bbai, raid\\u012bjum\\u0101 Zin\\u0101mais nezin\\u0101maj\\u0101 skaidro Latvijas Biomedic\\u012bnas p\\u0113t\\u012bjumu un studiju centra Zin\\u0101tnisk\\u0101s padomes priek\\u0161s\\u0113d\\u0113t\\u0101js J\\u0101nis Klovi\\u0146\\u0161.\\n\\n\\u0122en\\u0113tika liel\\u0101 m\\u0113r\\u0101 regul\\u0113 m\\u016bsu dz\\u012bvi, proti, nosaka, cik stipra b\\u016bs m\\u016bsu vesel\\u012bba, k\\u0101 ar\\u012b - vai un ko p\\u0101rmantosim no iepriek\\u0161\\u0113j\\u0101m paaudz\\u0113m. Ta\\u010du svar\\u012bga ir ne vien m\\u016bsu individu\\u0101l\\u0101 \\u0123en\\u0113tika, bet ar\\u012b tas, k\\u0101ds ir liel\\u0101kas popul\\u0101cijas genoms. \\u0160obr\\u012bd Latvijas iedz\\u012bvot\\u0101ji ir aicin\\u0101ti iesaist\\u012bties p\\u0113tniec\\u012bbas projekt\\u0101, kas zin\\u0101tniekiem Eiropas m\\u0113rog\\u0101 \\u013cautu ieg\\u016bt datus par vair\\u0101ku valstu iedz\\u012bvot\\u0101ju genomu, t\\u0101 saist\\u012bbu ar k\\u0101d\\u0101m saslim\\u0161an\\u0101m, un tas savuk\\u0101rt pal\\u012bdz\\u0113tu att\\u012bst\\u012bt vesel\\u012bbas apr\\u016bpi un pl\\u0101not profilaktiskus pas\\u0101kumus slim\\u012bb\\u0101m. Kas v\\u0113l interesanti - l\\u012bdz \\u0161im jau ieg\\u016btie dati no Latvijas iedz\\u012bvot\\u0101jiem \\u013c\\u0101vu\\u0161i noskaidrot k\\u0101du interesantu atkl\\u0101smi par latvie\\u0161iem un lietuvie\\u0161iem un to, k\\u0101 gadu t\\u016bksto\\u0161u laik\\u0101 m\\u016bsu genoms joproj\\u0101m glab\\u0101 p\\u0113das no sen\\u0101s mednieku-v\\u0101c\\u0113ju kult\\u016bras.\\n\\n"Jau tagad, ja ir \\u0101rsta \\u0123en\\u0113ti\\u0137is, kuram par vi\\u0146a pacientu ir atn\\u0101kusi kaut k\\u0101da inform\\u0101cija, pie\\u0146emsim, no diagnostikas laboratorijas \\u0101rzem\\u0113s, tad, visticam\\u0101k, t\\u0101 ir inform\\u0101cija:\\xa0"P\\u0113c m\\u016bsu inform\\u0101cijas, izskat\\u0101s, ka \\u0161im pacientam ir mut\\u0101cija "x", kas var\\u0113tu izrais\\u012bt \\u0161o slim\\u012bbu. Bet m\\u0113s neesam piln\\u012bgi p\\u0101rliecin\\u0101ti, jo m\\u0113s nezin\\u0101m, k\\u0101da ir \\u0161\\u0101da genoma vari\\u0101cijas sastopam\\u012bba Latvijas popul\\u0101cij\\u0101". T\\u0101tad m\\u0113s nevaram izskaidrot, mums pietr\\u016bkst datu. Ja \\u0161ai komp\\u0101nijai vai pa\\u0161am \\u0101rstam b\\u016btu piek\\u013cuve \\u0161\\u0101d\\u0101m Latvijas genoma references projektam, tad jau daudzas no atbild\\u0113m tiktu diezgan liel\\u0101 m\\u0113r\\u0101 uzreiz preciz\\u0113tas," skaidro J\\u0101nis Klovi\\u0146\\u0161. "Ja \\u0161\\u012b genoma izmai\\u0146a, t\\u0101tad mut\\u0101cija nav atrasta nekur citur pasaul\\u0113 vai Eirop\\u0101, vai atrasta tikai vienas slim\\u012bbas slimniekiem, tad skaidrs, ka vi\\u0146a ir \\u0161\\u012bs slim\\u012bbas izrais\\u012bt\\u0101ja. Savuk\\u0101rt, ja m\\u0113s redzam, varb\\u016bt, ka mums ir t\\u0101 \\u012bpatn\\u012bba, ka tie\\u0161i \\u0161\\u0101ds variants mums ir vienk\\u0101r\\u0161i visiem cilv\\u0113kiem, kas piln\\u012bb\\u0101 veseli. Un tad m\\u0113s vi\\u0146u varam izsv\\u012btrot no \\u0161\\u012b saraksti\\u0146a. Tie\\u0161i \\u0161\\u0101das lietas ir t\\u0101s, kuras tagad \\u0101rstiem \\u0123en\\u0113ti\\u0137iem pietr\\u016bkst taj\\u0101 lieto\\u0161an\\u0101.\\xa0 Protams, tas ir tikai viens mazs piem\\u0113rs, un t\\u0101du ir \\u013coti daudz, ko m\\u0113s varam izmantot, lai gan \\u0161eit, Latvij\\u0101, specifiski, gan lai visa Eiropa ar\\u012b kaut ko iem\\u0101c\\u012btos no katras valsts genoma."\\n\\nK\\u0101 \\u0161is genoms var\\u0113tu pal\\u012bdz\\u0113t medic\\u012bnas nozarei, proti, kontrol\\u0113t vai \\u0101rst\\u0113t k\\u0101das specifiskas saslim\\u0161anas, izv\\u0113l\\u0113ties medikamentus. Ja, m\\u0113s, piem\\u0113ram, iedom\\u0101jamies t\\u0101das saslim\\u0161anas k\\u0101 cukura diab\\u0113ts, astma, artr\\u012bts , vai izpratne par popul\\u0101cijas genomu pal\\u012bdz\\u0113s izprast da\\u017e\\u0101du slim\\u012bbu att\\u012bst\\u012bbu.\\n\\nJ\\u0101nis Klovi\\u0146\\u0161: Paties\\u012bb\\u0101, p\\u0113c jau pa\\u0161reiz uzkr\\u0101t\\u0101s inform\\u0101cijas, m\\u0113s varam, ja vien cilv\\u0113kiem ir pieejams genoms, uzb\\u016bv\\u0113t vi\\u0146am \\u0161\\u0101du potenci\\u0101lo risku saslimt ar katru no nosauktaj\\u0101m slim\\u012bb\\u0101m. M\\u0113s pa\\u0146emam datus no literat\\u016bras, ir algoritmi, ir speci\\u0101ls katalogs, kur\\u0101 m\\u0113s to uzb\\u016bv\\u0113jam. Kur ir probl\\u0113ma? Pirmk\\u0101rt, vi\\u0146\\u0161 b\\u016bs neprec\\u012bzs, t\\u0101p\\u0113c ka \\u0161ie dati ir n\\u0101ku\\u0161i no cit\\u0101m popul\\u0101cij\\u0101m, nevis no Latvijas. Un, k\\u0101 jau min\\u0113ju, tur var b\\u016bt t\\u0101das nelielas at\\u0161\\u0137ir\\u012bbas. Otrk\\u0101rt, vi\\u0146\\u0161 ir neprec\\u012bzs uz doto br\\u012bdi p\\u0113c b\\u016bt\\u012bbas, t\\u0101p\\u0113c ka mums nav v\\u0113l tik daudz zin\\u0101\\u0161anu par visiem genomu variantiem un vi\\u0146u saist\\u012bbu ar slim\\u012bb\\u0101m. Tas ir process, kur p\\u0113t\\u012bjumi v\\u0113l joproj\\u0101m turpin\\u0101s. Tre\\u0161ais, \\u0161\\u0101ds \\u0123en\\u0113tiskais risks uz t\\u0101d\\u0101m bie\\u017ei sastopamaj\\u0101m slim\\u012bb\\u0101m nenoz\\u012bm\\u0113, ka tas ir pagalam un viss cilv\\u0113kam, ka vairs nav izejas. M\\u016bsu slim\\u012bba veidojas, kombin\\u0113joties \\u0123en\\u0113tiskiem riskam un apk\\u0101rt\\u0113j\\u0101s vides faktoriem, respekt\\u012bvi, tam, ko m\\u0113s liekam sev\\u012b iek\\u0161\\u0101 vai nu p\\u0101rtikas veid\\u0101, vai varb\\u016bt dz\\u0113rienu, vai sm\\u0113\\u0137\\u0113\\u0161ana, pie\\u0146emsim, un citi nel\\u0101gi paradumi. Tas viss kombin\\u0113jas mums slim\\u012bbas veido\\u0161an\\u0101.\\n\\n(..) Viens piem\\u0113rs, kaut vai visiem labi zin\\u0101mais kr\\u016bts v\\u0113zis. Ja m\\u0113s zin\\u0101m, ka ir palielin\\u0101ts risks un uz doto br\\u012bdi m\\u0113s var\\u0113tu apr\\u0113\\u0137in\\u0101t, ka lielai da\\u013cai popul\\u0101cijas var\\u0113tu b\\u016bt \\u0161\\u0101ds \\u013coti paaugstin\\u0101ts risks, ja m\\u0113s b\\u016btu visus Latvijas cilv\\u0113kus izanaliz\\u0113ju\\u0161i. Tad var pied\\u0101v\\u0101t \\u0101tr\\u0101k skr\\u012bningu uzs\\u0101kt \\u0161iem cilv\\u0113kiem. \\u0160ie cilv\\u0113ki noteikti b\\u016bs ar\\u012b motiv\\u0113t\\u0101ki to dar\\u012bt, iet un regul\\u0101ri p\\u0101rbaud\\u012bt. P\\u0113c b\\u016bt\\u012bbas agr\\u012bni atkl\\u0101jot \\u0161o audz\\u0113ju, vi\\u0146u var ar\\u012b daudz veiksm\\u012bg\\u0101k iz\\u0101rst\\u0113t, nek\\u0101 tad, ja visai popul\\u0101cijai piem\\u0113ro \\u0161o skr\\u012bningu vien\\u0101 veid\\u0101, un ar\\u012b m\\u0113s k\\u0101 nemotiv\\u0113jamu cilv\\u0113ks to dar\\u012bt.'