TWiV 955: Clinical update with Dr. Daniel Griffin
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In his weekly clinical update Dr. Griffin discusses the four things to know about RSV,\\xa0the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease,\\xa0evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox,\\xa0tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection,\\xa0clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients,\\xa0effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy,\\xa0maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy,\\xa0impact of community masking on COVID-19,\\xa0Lifting Universal Masking in Schools \\u2013 Covid-19 Incidence among Students and Staff,\\xa0systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients,\\xa0comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti\\u2013SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19,\\xa0evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants,\\xa0monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy,\\xa0twice daily oral zinc in the treatment of patients with COVID-19,\\xa0cognitive deficits in long Covid-19,\\xa0severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and\\xa0long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.
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Links for this episode
- Four things\\xa0to know about RSV (Gates Foundation)
- The burden of\\xa0RSV\\xa0in healthy term-born infants in Europe (The Lancet)
- Diagnostic accuracy of\\xa0rapid tests\\xa0for Ebola (CMI)
- Accuracy of self-collected swabs for diagnosis of\\xa0Monkeypox\\xa0(CID)
- Tecovirimat\\xa0is effective against human monkeypox virus in vitro (Nature)
- Acute and postacute sequelae associated with\\xa0SARS-CoV-2 reinfection\\xa0(NatureMedicine)
- SARS-CoV-2\\xa0infection and recovery\\xa0in lung transplant recipients (Transplant Infectious Diseases)
- Effectiveness\\xa0of third COVID-19 vaccination during pregnancy (Nature Communications)
- Maternal antibody response and transplacental transfer following\\xa0infection or vaccination\\xa0(CID)
- Impact of\\xa0community masking\\xa0on COVID-19 (Science)
- Lifting\\xa0universal masking in schools (NEJM)
- Bebtelovimab fact sheet\\xa0for providers (FDA)
- Effectiveness of\\xa0Tixagevimab/Cilgavimab\\xa0for prophylaxis of COVID-19 (medRxiv)
- Effectiveness of Sotrovimab and Molnupiravir for\\xa0prevention\\xa0of severe COVID-19 outcomes (BMJ)
- Early adoption of\\xa0Anti\\u2013SARS-CoV-2\\xa0pharmacotherapies among US veterans (JAMA)
- PAXLOVID patient eligibility\\xa0screening checklist (FDA)
- Viral and symptom\\xa0rebound differences\\xa0between Paxlovid and untreated COVID-19 participants (medRxiv)
- Monoclonal antibodies\\xa0for treatment of SARS-CoV-2 during pregnancy (Annals of Internal Medicine)
- Remdesivir fact sheet\\xa0for providers (Veklury)\\xa0
- Twice daily oral zinc in the\\xa0treatment\\xa0of patients with COVID-19 (CID)\\xa0
- Cognitive deficits\\xa0in long COVID-19 (NEJM)
- Severe Neuro-COVID\\xa0associated\\xa0with peripheral immune signatures, autoimmunity and neurodegeneration (Nature Communications)
- Long-lasting symptoms\\xa0after an acute COVID-19 Infection (JAMA)
- Contribute to our\\xa0MicrobeTV fundraiser at PWB
- Dr. Griffin\\u2019s treatment guide (pdf)
- Letters read\\xa0on TWiV 955
- Timestamps by Jolene. Thanks!
Intro music is by\\xa0Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv