TWiV 936: Clinical update with Dr. Daniel Griffin
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In his weekly clinical update Dr. Griffin discusses\\xa0detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder,\\xa0severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68,\\xa0effects of vaccination and previous infection on Omicron infections in children,\\xa0COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states,\\xa0effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada,\\xa0nasal IgA wanes 9 months after hospitalization with COVID-19 and is not induced by subsequent vaccination,\\xa0\\xa0resistance of SARS-CoV-2 Omicron subvariant BA.4.6 to antibody neutralization,\\xa0persistent circulating SARS-CoV-2\\xa0spike associated with post-acute\\xa0COVID-19\\xa0sequelae, and\\xa0impact of COVID-19 vaccination on the risk of developing long-covid and on existing long-covid symptoms.
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Links for this episode
- Detection of poliovirus in\\xa0immunosuppressed child\\xa0(CDC)
- Severe respiratory illnesses\\xa0associated with rhinoviruses and/or enteroviruses (CDC)
- Effects of vaccination and previous\\xa0Omicron infection\\xa0in children (NEJM)
- COVID-19 hospitalizations\\xa0among vaccinated and unvaccinated adults (JAMA)
- Effectiveness of vaccines prior to\\xa0Omicron\\xa0(IDSA)
- Nasal iga\\xa0wanes 9 months after COVID hospitalization (medRxiv)
- Resistance of Omicron subvariant to\\xa0antibody neutralization\\xa0(BioRxiv)
- PAXLOVID patient eligibility\\xa0screening checklist (FDA)
- Remdesivir fact sheet\\xa0for providers (Veklury)\\xa0
- Bebtelovimab fact sheet\\xa0for providers (FDA)
- SARS-CoV-2 spike\\xa0is associated with post-acute sequelae (IDSA)
- Impact of vaccination on the risk of developing long-COVID (The Lancet)
- Contribute to\\xa0Floating Doctors fundraiser at PWB
- Dr. Griffin\'s treatment guide (pdf)
- Letters read\\xa0on TWiV 936
- Timestamps by Jolene. Thanks!
Intro music is by\\xa0Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv