TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar
b'
Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation.
Hosts:\\xa0Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler
Guests: Moshe Arditi and Ivet Behar
Subscribe (free):\\xa0iTunes,\\xa0Google Podcasts,\\xa0RSS,\\xa0email
Become a\\xa0patron\\xa0of\\xa0TWiV!
Links for this episode
- MIS-C in US children (NEJM)
- Superantigen in spike and T cell skewing in MIS-C (PNAS)
- MIS-C mimics toxic shock syndrome (J Allergy Clin Immunol)
- Antibody against bacterial superantigen blocks SARS-CoV-2 entry (Structure)
- Autoimmune signature of MIS-C in children (J Clin Invest)
- HLA1 associated T cell expansion in MIS-C (J Clin Invest)
- Passing of Bill Wold (one, two)
- Letters read on TWiV 815
- Timestamps by Jolene. Thanks!
Weekly Picks
Dickson \\u2013 \\xa0Mel Brooks
Kathy \\u2013 Dickson\\u2019s art show at Fordham
Rich \\u2013 Saildrone captures footage from inside Hurricane Sam
Vincent \\u2013 A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman
Listener Picks
Kathryn \\u2013 Project Drawdown and the book
Charles \\u2013 Arrowsmith by Sinclair Lewis
Intro music is by\\xa0Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv