TWiV 796: The vary hungry spike with Paul and Theodora
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Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.
Hosts:\\xa0Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Paul Bieniasz and Theodora Hatiziiouannou
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Links for this episode
- High genetic barrier for SARS-CoV-2 antibody escape (bioRxiv)
- Enhanced antibody one year after COVID-19 (Nature)
- Letters read on TWiV 796
- Timestamps by Jolene. Thanks!
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Intro music is by\\xa0Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv