TWiV 796: The vary hungry spike with Paul and Theodora
Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.
Hosts:\xa0Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Paul Bieniasz and Theodora Hatiziiouannou
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Links for this episode- High genetic barrier for SARS-CoV-2 antibody escape (bioRxiv)
- Enhanced antibody one year after COVID-19 (Nature)
- Letters read on TWiV 796
- Timestamps by Jolene. Thanks!
Dickson \u2013 NIF and Photon Science: fusion reaction generates 1.3 MJ
Brianne \u2013 The PCR Song
Rich \u2013 1) How Boston Dynamics\u2019 Spot Robot Works! 2) Inside the lab: How does Atlas work?3) Atlas | Partners in Parkour
Theodora \u2013 Kevin Parry turning into random objects
Vincent \u2013 Lex Fridman
Intro music is by\xa0Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv