TWiV 1037: Antibodies, the good (CoV), the bad (Ad), the beautiful
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TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses.
Hosts:\\xa0Vincent Racaniello,\\xa0Dickson Despommier,\\xa0Rich Condit,\\xa0Kathy Spindler, and\\xa0Brianne Barker
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Links for this episode
- MicrobeTV Discord Server
- MicrobeTV store at\\xa0Cafepress
- Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
- VITT-like disorder\\xa0after adenovirus infection (NEJM)
- The clot thickens (TWiV 842)
- Lessons from\\xa0VITT\\xa0(Nat Rev Immunol)
- Pan-sarbecovirus\\xa0neutralizing mAb (Sci Adv)
- Letters read\\xa0on TWiV 1037
- Timestamps by\\xa0Jolene. Thanks!
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Intro music is by\\xa0Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
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