TWiV 1001: Clinical update with Dr. Daniel Griffin
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In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in fall-winter, French Mpox cluster includes fully vaccinated patients, two individuals with potential Mpox virus reinfection, epidemiologic and clinical features of Mpox-associated deaths, FDA authorizes changes to simplify use of bivalent mRNA COVID-19 vaccines, SARS-CoV-2 during Omicron variant predominance among infants born to people with SARS-CoV-2, severe maternal morbidity and mortality of pregnant patients with COVID-19 infection during the early pandemic period in the US, sickness presenteeism in healthcare workers during the COVID-19 pandemic, ventilation improvements among k\\u201312 public school districts, risk factors and vectors for SARS-CoV-2 household transmission, SARS-CoV-2 neutralizing antibodies after bivalent versus monovalent, durability of bivalent boosters against Omicron subvariants, Nirmatrelvir and risk of hospital admission or death in adults with COVID-19, evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19, effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support\\u2013free days in patients hospitalized with COVID-19, efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19, higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support, risk of autoimmune diseases in patients with COVID-19, definition of post\\u2013COVID-19 condition among published research studies, and sleep disturbance severity and correlates in post-acute sequelae of COVID-19.\\xa0
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Links for this episode
- Update on\\xa0vaccine-derived\\xa0poliovirus outbreaks (CDC)
- The dream\\xa0of wiping out polio might need a rethink (NPR)
- Risk of death in patients hospitalized for\\xa0COVID-19 vs influenza\\xa0(JAME)
- French mpox cluster\\xa0includes fully vaccinated patients (CIDRAP)
- Two individuals with potential\\xa0Monkeypox reinfection\\xa0(The Lancet)
- Epidemiologic and clinical\\xa0features of Mpox-associated deaths (CDC)
- FDA authorizes changes to simplify use of\\xa0Bivalent mRNA COVID-19 vaccines\\xa0(FDA)
- Omicron variant predominance\\xa0among infants born to people with SARS-CoV-2 (Pediatrics)
- Severe maternal morbidity and mortality of\\xa0pregnant patients\\xa0with COVID-19 (JAMA)\\xa0
- Sickness presenteeism\\xa0in healthcare workers during the COVID-19 pandemic (ICHE)
- Ventilation improvements among K\\u201312\\xa0public school districts\\xa0(CDC)
- Risk factors and vectors\\xa0for SARS-CoV-2 household transmission (The Lancet)
- SARS-CoV-2 neutralising antibodies after\\xa0bivalent vs monovalent\\xa0(The Lancet)
- Durability\\xa0of bivalent boosters against Omicron subvariants (NEJM)
- Nirmatrelvir and\\xa0risk of hospital admission or death\\xa0in adults with COVID-19 (BMJ)
- Real world effectiveness\\xa0of Monoclonal Antibodies for treatment of COVID-19 (AIM)
- Study on ACE inhibitor and ARB effect on\\xa0COVID-19 patient outcomes\\xa0(JAMA)
- Efficacy and safety\\xa0of Anakinra plus standard of care for patients with severe COVID-19 (JAMA)
- High-dose corticosteroids in\\xa0non-ventilated COVID-19 patients\\xa0with hypoxia (The Lancet)
- Risk of\\xa0autoimmune diseases\\xa0in patients with COVID-19 (eClinical)
- Definition of\\xa0post\\u2013COVID-19\\xa0condition (JAMA)
- Sleep disturbance\\xa0severity and correlates in Post-acute Sequelae of COVID-19 (JGIM)
- Contribute to our\\xa0ASTMH fundraiser at PWB
- Letters read\\xa0on TWiV 1001
- Timestamps by\\xa0Jolene. Thanks!
Intro music is by\\xa0Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
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