TWiP 116: One drug to rule them all

Published: Sept. 11, 2016, 12:05 a.m.

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Hosts:\\xa0Vincent Racaniello,\\xa0Dickson Despommier,\\xa0and Daniel Griffin

The\\xa0TWiPtoids\\xa0solve the case of the Thai Fisherman with Chronic Diarrhea, and reveal a potential new drug for treatment of leishmaniasis, Chagas diseases, and sleeping sickness.

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Case Study for TWiP 116

This week\'s case involves no math. 36 year old Thai man from the northeast part of the country. Comes in with abdominal distention. Eats a normal Thai diet - Som Tam, Koi Pla, lots of rice. Feels well, came in because he is getting yellowing of skin and whites of eyes - jaundiced. Previously healthy, no prior med prob or surgery. No diseases running in family. Fisherman in the northeast (freshwater). Wife and many children, monogamous, HIV negative. Lives in jungle area, near river, many dogs, chickens, monkeys, goats, cows, pigs. Bathroom is outside. No fever, thin. Distention going on for months. Getting bigger. Exam: jaundiced, has large palpable non-tender mass below liver on his right side. No enlarged liver or spleen. No travel.\\xa0

Send your case diagnosis, questions and comments to\\xa0twip@microbe.tv

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