Three exciting approaches to cancer research

Published: May 7, 2021, 6:56 p.m.

The American Cancer Society is committed to maintaining a broad cancer research portfolio\u2014any type of cancer, within any part of the cancer research continuum.\n\nThis episode is a perfect example of this commitment and features three cancer researchers from the UPMC Hillman Cancer Center. \n\nKathy Shair, PhD, studies how the Epstein-Barr virus causes cancer. Sarah Hengel, PhD, is investigating why unrepaired DNA leads to cancer. And Yuri Bunimovich, MD, PhD, conducts research into the role of our body\u2019s nerves in melanoma growth.\n\n1:47 \u2013 Yuri Bunimovich, MD, PhD, is Assistant Professor in the Department of Dermatology and member of the Cancer Immunology and Immunotherapy program at Hillman Cancer Center\n\nSarah Hengel, PhD, is an American Cancer Society postdoctoral fellow at the Hillman Cancer Center in the Department of Pharmacology and Chemical Biology in the Kara Bernstein lab.\n\nKathy Shair, PhD, is Assistant Professor of Microbiology and Molecular Genetics and an investigator in the Cancer Virology program at the Hillman Cancer Center\n\n3:11 \u2013 Dr. Shair on how her lab is focused on understanding how chronic infections can turn bad and result in cancer\n\n4:13 \u2013 Dr. Hengel\u2019s research into a subset of breast and ovarian cancers\n\n6:17 \u2013 Dr. Bunimovich on the role of nerves in the tumor microenvironment in melanoma and other cancers\n\n12:13 \u2013 Dr. Shair on recent advancements that help us understand the circumstances under which the Epstein-Barr virus can lead to cancer\n\n22:24 \u2013 Dr. Hengel explains how our improved understanding of different mutations is leading to more personalized therapies\n\n26:38 \u2013 Dr. Bunimovich explains how melanoma can injure nerves, creating an immune-suppressive environment that protects the melanoma from the body\u2019s immune response.\n\n35:16 \u2013 Dr. Shair on how Epstein-Barr viruses\u2019 interference with DNA repair can be used to our advantage \n\n38:00 \u2013 Dr. Hengel on how gathering more information about these mutations is critical to developing novel therapeutic targets\n\n40:29 \u2013 The three aspects of his research Dr. Bunimovich is most excited about \n\n45:28 \u2013 Dr. Shair and Dr. Hengel talk DNA repair and studying cancer in model organisms\n\n47:21 \u2013 Dr. Bunimovich and Shair on viruses and cancers\n\n51:42 \u2013 The impact of ACS funding\n\n53:45 \u2013 A message for cancer patients, survivors, and caregivers