Suicidal thoughts, behaviors, and event-related potentials: A meta-analysis

Published: May 1, 2020, 10 a.m.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.29.069005v1?rss=1 Authors: Gallyer, A. J., Dougherty, S. P., Burani, K., Albanese, B. J., Joiner, T. E., Hajcak, G. Abstract: Suicidal thoughts and behaviors (STBs) are thought to be the result, at least in part, of abnormalities in various neural systems. Event-related potentials (ERPs) are a useful method for studying neural activity, and can be leveraged to study neural deficits related to STBs, but it is unknown how effective ERPs are at differentiating various STB groups. The present meta-analysis examined how well ERPs can differentiate those with and without suicidal ideation (SI), suicide attempts (SA), and those determined to be at different levels of suicide risk, or suicidality. Our meta-analysis included 192 effect sizes from 24 studies. We used a random effects meta-analysis and found a small-to-moderate relationship between ERPs and STBs. However, we also found evidence that the literature may be suffering from small sample publication bias. Our results suggest that ERPs may compliment other approaches, such as fMRI, in the study of the neurobiology of individuals with STBs. However, the clinical utility of ERPs to predict STBs remains to be tested, and larger samples are needed to confirm the results of the present meta-analysis. Copy rights belong to original authors. Visit the link for more info