Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.03.235044v1?rss=1 Authors: Holly, E. N., Davatolhagh, M. F., Espana, R. A., Fuccillo, M. V. Abstract: Low-threshold spiking interneurons (LTSIs) in the dorsomedial striatum are potent modulators of goal-directed learning. Here, we uncover a novel function for LTSIs in locally and directly gating striatal dopamine, using in vitro fast scan cyclic voltammetry as well as in vivo GRAB-DA sensor imaging and pharmacology during operant learning. We demonstrate that LTSIs, acting via GABAB signaling, attenuate dopamine release, thereby serving as local coordinators of striatal plasticity. Copy rights belong to original authors. Visit the link for more info