Psilocybin rescues sociability deficits in an animal model of autism

Published: Sept. 10, 2020, 5:02 p.m.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.09.289348v1?rss=1 Authors: Mollinedo-Gajate, I., Song, C., Sintes-Rodriguez, M., Whelan, T., Soula, A., Selimbeyoglu, A., Hurley, S., Knöpfel, T. Abstract: Autism spectrum disorder (ASD) is characterized by core deficits in social interaction. The classic serotonergic psychedelic psilocybin has been suggested as a therapeutic agent that may ameliorate in the core symptomology of ASD. We found that the acute response to psilocybin was attenuated in the prenatal valproic acid exposure mouse model of ASD, and importantly, psilocybin rescued the social behavioural abnormalities present in these ASD model mice. Copy rights belong to original authors. Visit the link for more info