Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.17.386276v1?rss=1 Authors: Bathelt, J., Geurts, H. M., Borsboom, D. Abstract: Network approaches that investigate the interaction between symptoms and behaviours have opened new ways of understanding psychological phenomena in health and disorder in recent years. In parallel, network approaches that characterise the interaction between brain regions have become the dominant approach to understanding brain function in neuroimaging research. Combining these parallel approaches would enable new insights into the interaction between behaviours and their brain-level correlates. In this paper, we introduce a methodology for combining network psychometrics and network neuroscience. This approach utilises the information from the psychometric network to obtain neural correlates that are associated with each node in the psychometric network (network-based regression). Moreover, we combine the behavioural variables and their neural correlates in a joint network to characterise their interactions. We illustrate the approach by highlighting the interaction between the triad of autistic traits and their resting-state functional connectivity associations. To this end, we utilise data from 172 male autistic participants (10-21 years) from the autism brain data exchange (ABIDE, ABIDE-II) that completed resting-state fMRI and were assessed using the autism diagnostic interview (ADI-R). Our results indicate that the network-based regression approach can uncover both unique and shared neural correlates of behavioural measures. In addition, because the shared variance between behavioural measures is controlled for in the approach, the methodology enables us to isolate mechanisms at the brain-level that are unique to particular behavioural variables. For instance, our example analysis indicates that the overlap between communication and social dif[fi]culties is not re[fl]ected in the overlap between their functional brain correlates. Copy rights belong to original authors. Visit the link for more info