Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.18.255992v1?rss=1 Authors: Clark, I. A., Callaghan, M. F., Weiskopf, N., Maguire, E. A. Abstract: Individual differences in scene imagination, autobiographical memory recall, future thinking and spatial navigation have long been linked with hippocampal structure in healthy people, although evidence for such relationships is, in fact, mixed. Extant studies have predominantly concentrated on hippocampal volume. However, it is now possible to use quantitative neuroimaging techniques to model different properties of tissue microstructure in vivo such as myelination and iron. Here we investigated whether performance on scene imagination, autobiographical memory, future thinking and spatial navigation tasks was associated with hippocampal grey matter tissue microstructure. MRI data were collected using a multi-parameter mapping protocol from a large sample of 217 young, healthy adult participants with widely-varying task performance. We found little evidence that hippocampal grey matter tissue microstructure was related to task performance. This was the case using different analysis methods (voxel-based quantification, partial correlations), when whole brain, hippocampal regions of interest, and posterior:anterior hippocampal ratios were examined, and across different participant sub-groups (divided by gender, task performance). Variations in hippocampal grey matter tissue microstructure may not, therefore, explain individual differences in performance on hippocampal-dependent tasks in young, healthy individuals. Copy rights belong to original authors. Visit the link for more info