Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.13.200113v1?rss=1 Authors: Dzyubenko, E., Fleischer, M., Manrique-Castano, D., Borbor, M., Kleinschnitz, C., Faissner, A., Hermann, D. M. Abstract: Maintaining the balance between excitation and inhibition is essential for the appropriate control of neuronal network activity. Sustained excitation-inhibition (E-I) balance relies on the orchestrated adjustment of synaptic strength, neuronal activity and network circuitry. While growing evidence indicates that extracellular matrix (ECM) of the brain is a crucial regulator of neuronal excitability and synaptic plasticity, it remains unclear whether and how ECM contributes to neuronal circuit stability. Here we demonstrate that the integrity of ECM supports the maintenance of E-I balance by retaining inhibitory connectivity. Depletion of ECM in mature neuronal networks preferentially decreases the density of inhibitory synapses and the size of individual inhibitory postsynaptic scaffolds. After ECM depletion, inhibitory synapse strength homeostatically increases via the reduction of presynaptic GABAB receptors. However, the inhibitory connectivity reduces to an extent that inhibitory synapse scaling is no longer efficient in controlling neuronal network state. Our results indicate that the brain ECM preserves the balanced network state by stabilizing inhibitory control. Copy rights belong to original authors. Visit the link for more info