Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.29.123869v1?rss=1 Authors: Fitzgerald, M., Pritschet, L., Santander, T., Grafton, S. T., Jacobs, E. G. Abstract: The cerebellum contains the vast majority of neurons in the brain and houses distinct functional networks that constitute at least two homotopic maps of the cerebrum. While the functional organization of the human cerebellum has been characterized, the influence of sex steroid hormones on intrinsic cerebellar network dynamics has yet to be established. Here, we investigated the extent to which endogenous fluctuations in estradiol and progesterone alter functional cerebellar networks at rest in a woman densely sampled over a complete menstrual cycle (30 consecutive days). Edgewise regression analysis revealed negative associations between sex hormones and cerebellar coherence, with progesterone showing more pronounced negative associations relative to estradiol. Graph theory metrics probed sex hormones' influence on topological brain states, revealing relationships between sex hormones and intra- and inter- network integration in Ventral Attention, Dorsal Attention, and Somato-Motor Networks. Together, these results suggest that the intrinsic dynamics of the cerebellum are intimately tied to day-by-day changes in sex hormones. Copy rights belong to original authors. Visit the link for more info