Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.09.374637v1?rss=1 Authors: Manoel, D., Makhlouf, M., Arayata, C. J., Sathappan, A., Da'as, S., Abdelrahman, D., Selvaraj, S., Hasnah, R., Mainland, J. D., Gerkin, R. C., Saraiva, L. R. Abstract: Odor perception in non-humans is poorly understood. Here, we generated the most comprehensive murine olfactory ethological atlas to date, consisting of behavioral responses to a diverse panel of 73 odorants, including 12 at multiple concentrations. These data revealed that the mouse behavior is incredibly diverse, and changes in response to odor identity and intensity. Using only behavioral responses, ~30% of the 73 odorants could be identified with high accuracy (>96%) by a trained classifier. Mouse behavior occupied a low-dimensional space, consistent with analyses of human olfactory perception. While mouse olfactory behavior is difficult to predict from the corresponding human olfactory percept, three fundamental properties are shared: odor valence is the primary axis of olfactory perception; the physicochemical properties of odorants can predict the olfactory percept; and odorant concentration quantitatively and qualitatively impacts olfactory perception. These results provide a template for future comparative studies of olfactory percepts among species. Copy rights belong to original authors. Visit the link for more info