Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.29.273755v1?rss=1 Authors: Zhang, C.-Y., Zhang, N.-H. Abstract: Structure and stiffness of nucleic acids are closely related to viral infectivity. The article is aimed to clarify a recent controversy on structure variation of viral DNA in temperature-dependent experiments. A multi-scale correlation between microscopic structure of viral DNA and its bulk stiffness is formulated by presenting a two-zone mesoscopic free energy model. Results reveal that the increasing temperature promotes DNA structure transformation from order to disorder, and leads to size effect on temperature-dependency of stiffness and structure of viral DNA. Copy rights belong to original authors. Visit the link for more info