Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.22.262451v1?rss=1 Authors: Kang, J., Koehler, R. C., Adams, S., Graham, E. M., Boctor, E. M. Abstract: We present a light-emitting diode (LED)-based transcranial photoacoustic measurement (LED-trPA) of oxyhemoglobin (HbO2) saturation at superior sagittal sinus (SSS) in hypoxic neonatal piglets. The optimal LED imaging wavelengths and frame averaging scheme were determined based on in vivo characterization of transcranial sensitivity. Based on the framework (690/850 nm with >20 frame averaging), graded hypoxia was successfully identified in neonatal piglets in vivo with less than 10.0 % of root mean squared error (RMSE). This preclinical study suggests the feasibility of a rapid, cost-effective, and safe LED-trPA monitoring of perinatal hypoxia-ischemia and prompt interventions for clinical use. Copy rights belong to original authors. Visit the link for more info