Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.02.259200v1?rss=1 Authors: Zhang, M., Tang, W., Ying, W. Abstract: Autofluorescence (AF) of skin holds great promise for non-invasive diagnosis of diseases. Our previous study has indicated that keratin-based AF of skin holds great promise to become a novel biomarker for diagnosis of multiple major diseases, including lung cancer, acute ischemic stroke, Parkinson diseases, stable coronary artery disease and myocardial infarction. It is critical to investigate the mechanisms underlying the increased AF of the skin of the patients. Our previous study has shown that development of lung cancer can induce increased green AF of the skin of mice, while the mechanisms underlying the increased AF have remained unclear. We hypothesized that the inflammation in the mice with lung cancer is causative to the increased AF. Our study found that the anti-inflammation drug indomethacin virtually abolished the lung cancer-induced increase in the green AF of the skin. We further found that the AF was originated from the epidermis of the mice. Our findings have provided critical information for understanding the mechanisms underlying the lung cancer-induced increase in the epidermal green AF, indicating that at least for lung cancer, the disease-induced increase in the AF of the skin mainly results from increased inflammation in the body. Copy rights belong to original authors. Visit the link for more info