Cell-to-cell Mathematical Modeling of Arrhythmia Phenomena in the Heart

Published: July 29, 2020, 2:02 a.m.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.28.225755v1?rss=1 Authors: Lopez, G., Nicolas, A., Roman, G., Godinez, R., Castro, M. A. Abstract: With an aperiodic, self-similar distribution of two-dimensional arrangement of atrial cells, it is possible to simulate such phenomena as Fibrillation, Fluttering, and a sequence of Fibrillation-Fluttering. The topology of a network of cells may facilitate the initiation and development of arrhythmias such as Fluttering and Fibrillation. Using a GPU parallel architecture, two basic cell topologies were considered in this simulation, an aperiodic, fractal distribution of connections among 462 cells, and a chessboard-like geometry of 60x60 and 600x600 cells. With a complex set of initial conditions, it is possible to produce tissue behavior that may be identified with arrhythmias. Finally, we found several sets of initial conditions that show how a mesh of cells may exhibit Fibrillation that evolves into Fluttering. Copy rights belong to original authors. Visit the link for more info