eQTpLot: an R package for the visualization and colocalization of eQTL and GWAS signals

Published: Aug. 26, 2020, 3:01 a.m.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.26.268268v1?rss=1 Authors: Drivas, T. G., Lucas, A., Ritchie, M. D. Abstract: Summary: Genomic studies increasingly integrate expression quantitative trait loci (eQTL) information into their analysis pipelines, but few tools exist for the visualization of colocalization between eQTL and GWAS results. To address this issue, we developed the intuitive R package eQTpLot, which takes as input GWAS and eQTL summary statistics to generate a series of plots visualizing colocalization, correlation, and enrichment between eQTL and GWAS signals for a given gene-trait pair. We believe eQTpLot will prove a useful tool for investigators seeking a convenient and customizable visualization of genomic data colocalization. Availability and Implementation: The eQTpLot R package and tutorial are available at https://github.com/RitchieLab/eQTpLot Contact: theodore.drivas@pennmedicine.upenn.edu Copy rights belong to original authors. Visit the link for more info