Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.17.254805v1?rss=1 Authors: Laubach, Z. M., Greenberg, J. R., Turner, J. W., Montgomery, T., Pioon, M. O., Smale, L., Cavalcante, R., Padmanabhan, K. R., Lalancette, C., vonHoldt, B., Faulk, C. D., Dolinoy, D. C., Holekamp, K. E., Perng, W. Abstract: In a wild population of spotted hyenas, we tested the hypothesis that maternal care during the first year of life and social connectedness during two periods of early development lead to differences in DNA methylation and fecal glucocorticoid metabolites (fGCMs) later in life. We found that although maternal care and social connectedness during the communal den dependent period were not associated with fGCMs, greater social connectedness after hyenas leave their communal den is associated with lower adult fGCMs. Additionally, more maternal care and social connectedness after leaving the communal den corresponded with higher global (%CCGG) DNA methylation. Finally, we identified multiple DNA methylation biomarkers near genes involved in inflammation that may link maternal care and stress phenotype. Our findings suggest that both maternal care during the first year of life and social connections after leaving the den influence DNA methylation and contribute to a developmentally plastic stress response. Copy rights belong to original authors. Visit the link for more info