Episode 4 - Alpha ketoglutarate
Show notes
Night Shift banter- 00:20
Kenopsia flex - 02:10
Daylight savings and heart attacks - 02:50
Our intro to AKG / the Gym - 04:10
Bro science - 05:20
Molecular waste not want not - 05:50
The conceptual challenge -07:25
TCA Cycle and Adolf - 10:20
Link to NAD+/NADH and low energy state - 12:00
Hierarchies of ageing - 13:30
Safety and animal studies - 14:10
Confusing mTOR interactions - 15:50
Muscle hypertrophy and health-span - 18:55
Pharmacokinetics -22:45
Does cellular ageing matter? - 25:00
Parabiosis - 28:30
Frailty - 31:15
In praise of In Time - 34:14
Mechanisms AKG - 38:00
An unknown dose - 41:00
Arginine - 42:18
The Bro Science Study - 44:40
Dosing hypothesis? - 46:45
Our previous studies - 49:30
Falling off the horse - 51:20
How we motorcycle - 52:30