Episode 3 - Senescence
Jahan and Terry make inroads by tackling the very big topic of senescence and the role it plays in ageing. An exciting area where it seems we can really make a difference by not only halting the ageing process but perhaps even starting to reverse it.
Show Notes:
Fasting hit piece- 1:15
Introduction to senescence- 6:25
Senescence metaphor- 7:44
Inflammaging & examples- 15:14
Pros and cons of senescence (Antagonistic Pleiotropy): 19:25
Regulating bone growth: 22:55
Cell to organism connection: 24:20
Evidence showing negative effects of senescence (for senolytics)- 28:15
Transgenic mice- 30:22
Senolytic example (Dasatinib and Quercetin)- 33:22
Senolytics and osteoarthritis- 38:00
Antibiotics- 40:46
Muscle and ageing- 43:17
Stem cells- 45:35
Senescence and cancer- 48:18
Telomeres- 50:05
Bret Weinsteins problem with lab mice- 53:17
Caffeine & Turmeric- 58:20
Disclaimer- 1:02:50