MTS10 - Anthony Maurelli - Black Holes and Antivirulence Genes

Published: Nov. 25, 2008, 5:43 p.m.

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Tony Maurelli is a professor of microbiology and immunology in the F. Edward H\\xe9bert School of Medicine at the Uniformed Services University of the Health Sciences in Bethesda, Maryland.\\xa0 Dr. Maurelli\\u2019s major research interest lies in the genetics of bacterial pathogenesis \\u2013 the genetic nuts and bolts of how bacteria infect humans and make us sick.

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Dr. Maurelli\\u2019s work has uncovered \\u201cantivirulence genes\\u201d in Shigella flexneri, a major cause of dysentery and food borne illness.\\xa0 This is an interesting concept: antivirulence genes undermine pathogenicity, so they must be broken or dropped from the genome for a bacterium to take good advantage of a host and cause disease.\\xa0 These genes are a hindrance, so to become an effective pathogen, Shigella must stop using them.

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In this interview, I talked with Dr. Maurelli about antivirulence genes, about whether the naming system for bacteria should be fixed, and about his favorite bacteria.

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