Podcasts Science Meet The Microbiologist 071: Neglected Tropical Diseases and Vaccine Advocacy with Peter Hotez

071: Neglected Tropical Diseases and Vaccine Advocacy with Peter Hotez

Published: Dec. 8, 2017, 12:50 a.m.

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Peter Hotez talks about neglected tropical diseases: what are they, where are they found, and where did the term \\u201cneglected tropical disease\\u201d come from, anyway? Hotez discusses some of the strategies his and other groups are using for vaccine development, and his work as an advocate for childhood vaccines and global health.

Host: Julie Wolf

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Julie\'s biggest takeaways:

  • Renaming \\u201cother diseases\\u201d - a large collection of disparate diseases such as schistosomiasis, leishmaniasis, and onchocerciasis (also called river blindness) - as \\u201cneglected tropical diseases\\u201d by Hotez and colleagues was integral to bringing attention to the diseases of the bottom billion, people that live on less than one U.S. Dollar per day.

  • Neglected tropical diseases are often chronic and debilitating without high mortality. These diseases trap people in poverty due to their long-term effects. The NTDs are often associated with terrible stigma that can lead to additional challenges for affected populations.

  • Neglected tropical diseases are found worldwide, in rich and poor countries. The poorest peoples living in the G20 countries (and Nigeria) now account for most of the world\\u2019s NTDs.

  • Parasitic infections present challenges for vaccine design, but reverse vaccinology may be a useful strategy. Reverse vaccinology mines genomes to identify promising vaccine candidates in silico, which are then narrowed sequentially for those that are expressed on the bacterial surface, immunogenic, and ultimately protective against disease. This strategy has worked for Neisseria meningitidis, and Hotez is hopeful that it will produce effective vaccines for the parasitic infections he studies.

  • The tradition of individual fields and departments, combined with the old-fashioned notion that scientists needn\\u2019t spend their time engaging with the public, has led to flatlined budgets and the rise of anti-science movements. Scientists need to engage the public to ensure the future of science and science-based policy.

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Featured Quotes (in order of appearance):

\\u201cThe concept of \\u2018neglected tropical diseases\\u2019 was very much born out of the Millennium Development Goals launched in the year 2000.\\u201d
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\\u201cTreating NTDs in rich countries \\u201cis not a resource problem; it\\u2019s an awareness problem.\\u201d

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\\u201cIf you want to enter global health, we need as many people with a scientific background to go into business and law and international relations as we need to go into traditional scientific pathways\\u201d
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\\u201cMany involved in the antivaccine movement disproportionately involve either parents who are affluent or educated, or both: those who know just enough to do a google search but without the background to separate the garbage from the important stuff. And of course the anti-vaccine groups are deliberately misleading.\\u201d
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\\u201cResearch America found that 81% of Americans can\\u2019t name a living scientist. That\\u2019s our fault. We\\u2019re so inward looking that we aren\\u2019t taking the time to do public engagement.\\u201d
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Links for this episode

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