Oliver Sackss functional paralysis; progressive multifocal leukoencephalopathy
b'In 1974 Oliver Sacks was hiking through a remote part of Norway when he suffered a nasty injury to one leg. Although he managed to get to help and was successfully operated on, he struggled to relearn to walk and felt alienated from the limb. Jon Stone (consultant neurologist in the Department of Clinical Neurosciences, University of Edinburgh) explains why from Sacks\\u2019s writing he thinks this was a case of functional paralysis, and why the account is so valuable.And progressive multifocal leukoencephalopathy: the rare but potentially fatal condition which can follow monoclonal antibody treatment. Dirk Mentzer (Department of Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institute, Germany) talks us through his new case definition, and offers some clinical advice.See also:\\u2018A Leg to Stand On\\u2019 by Oliver Sacks: a unique autobiographical account of functional paralysis http://tinyurl.com/bc4oavvCase definition for progressive multifocal leukoencephalopathy following treatment with monoclonal antibodies http://tinyurl.com/aa2pmsqA poster presentation of the PML case definition http://tinyurl.com/b2db26e'