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In this episode with special guest Paul van Susante, Assistant Professor at Michigan Tech University, we discussed many of the challenges that are unique to Mars for ISRU. 
Challenges such as:

•  The differences between Lunar and Martian regolith.
• The ease of extracting water in high enough concentrations from regolith.
• The technological barriers we need to cross to carry out effective, scalable ISRU on Mars and other planetary bodies.