A review article in the October 2010 issue of Gastroenterology looks at the mechanism of action of proton pump inhibitors, summarizes the data available on the putative adverse effects of PPI therapy, and proposes guidelines for clinicians who prescribe these agents to limit the potential for adverse outcomes. Dr. Kuemmerle speaks to co-author Dr. David Metz of the University of Pennsylvania School of Medicine. Plus, a rundown of top stories from this month's issue of GI and Hepatology News.