Technical advances have led to stool DNA (sDNA) tests that might accurately detect neoplasms on both sides of the colorectum. A study in the February issue of Gastroenterology assessed colorectal neoplasm detection by a next-generation sDNA test and effects of covariates on test performance. Dr. Kuemmerle speaks to first author Dr. David A. Ahlquist of the Mayo Clinic, Rochester, MN; Plus, a rundown of top stories from this month's issue of GI and Hepatology News.