Acute-on-chronic liver failure (ACLF) develops in patients with chronic liver disease and has high mortality. A study in the March issue of Gastroenterology examined whether mobilization of bone marrow–derived stem cells with granulocyte colony–stimulating factor (G-CSF) might promote hepatic regeneration for patients with acute-on-chronic liver failure (ACLF). Dr. Kuemmerle speaks to author Dr. Shiv K. Sarin of GB Pant Hospital, New Delhi, India; Plus, a rundown of top stories from this month's issue of GI and Hepatology News.