An article in the May 2010 issue of Gastroenterology reflects on the 2008 multi-society guidelines for colorectal cancer (CRC) screening, stressing that doctors should keep an open mind and consider all evidence when deciding which test to recommend for patients. Dr. Kuemmerle speaks with the author of this “Mini-Reviews and Perspectives” article, Dr. James E. Allison, Clinical Professor of Medicine Emeritus at the University of California, San Francisco.