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Paul A. Offit, MD, an attending physician in the Division of Infectious Diseases & the director of the Vaccine Education Center at the Children\\u2019s Hospital of Philadelphia, a professor of vaccinology and pediatrics at the University of Pennsylvania, and member of the FDA\'s vaccine advisory committee chats with Trey Elling about YOU BET YOUR LIFE: FROM BLOOD TRANSFUSIONS TO MASS VACCINATION, THE LONG AND RISKY HISTORY OF MEDICAL INNOVATION. Questions include:

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• Did any ethical issues arrive with human-to-human heart transplants before brain death was internationally defined in 1968? (03:12)
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• Why were blood transfusions disappear after several were performed in the mid-1600s? (05:58)
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• How did the rise of HIV/AIDS in the 1980s impact blood transfusions? (08:08)
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• How was nationalism a hindrance to anesthesia in its early days? (10:14)
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• Regarding antibiotics, what was the Elixir Sulfanilamide disaster of 1937? (14:35)
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• When examining the history of vaccines, why did he focus on the creation and administration of the polio vaccine? (17:25)
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• What are x-rays? (28:55)
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• What does mustard gas have to do with the advent of chemotherapy? (31:05)
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• Does the general public need a COVID vaccine booster six months after receiving their initial shots? (39:07)
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• How should those with immunity acquired from previous infection be looked at? (41:55)
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