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121 episodes

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Assembly and symmetry of the fungal E3BP-containing core of the Pyruvate Dehydrogenase Complex

Published: Aug. 14, 2020, 6:01 p.m.
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Listed in: Science

A Strategy to Assess the Cellular Activity of E3 Ligases against Neo-Substrates using Electrophilic Probes

Published: Aug. 14, 2020, 5:03 p.m.
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Listed in: Science

The RNA-binding protein Puf5 buffers mRNA levels against chromatin-mediated changes in nascent transcription

Published: Aug. 14, 2020, 5:03 p.m.
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Listed in: Science

The Macerprep: a minimalist kit- and enzyme-free high-yield miniprep utilising alkaline lysis and alkaline hydrolysis principles

Published: Aug. 14, 2020, 4:03 p.m.
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Listed in: Science

Maternal high fat diet alters lactation-specific miRNA expression and programs the DNA methylome in the amygdala of female offspring

Published: Aug. 14, 2020, 4:03 p.m.
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Homologous recombination defects in Shwachman-Diamond syndrome and Diamond-Blackfan anemia

Published: Aug. 14, 2020, 10:03 a.m.
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Listed in: Science

UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import

Published: Aug. 14, 2020, 10:03 a.m.
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Structure Basis of Cav1.1 Modulation by Dihydropyridine Compounds

Published: Aug. 14, 2020, 10:03 a.m.
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Creb5 establishes the competence for Prg4 expression in articular cartilage

Published: Aug. 12, 2020, 8:01 a.m.
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KIAA1841, a novel SANT and BTB domain-containing protein, inhibits class switch recombination

Published: Aug. 12, 2020, 5:03 a.m.
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TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2

Published: Aug. 12, 2020, 4:02 a.m.
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Transcriptome profiling of ulcerative colitis mouse model suggests biomarkers and therapeutic targets for human colitis

Published: Aug. 12, 2020, 2:07 a.m.
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A single-cell method to map higher-order 3D genome organization in thousands of individual cells reveals structural heterogeneity in mouse ES cells

Published: Aug. 12, 2020, 2:07 a.m.
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Structural and molecular basis for protein-stimulated ribosomal frameshifting in Theiler's murine encephalomyelitis virus

Published: Aug. 11, 2020, 4:05 p.m.
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Structural studies of Cardiovirus 2A protein reveal the molecular basis for RNA recognition and translational control

Published: Aug. 11, 2020, 4:05 p.m.
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The RAD51 recombinase protects mitotic chromatin in human cells

Published: Aug. 11, 2020, 4:05 p.m.
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Anti-pausing activity of region 4 of the RNA polymerase σ subunit and its regulation by σ-remodeling factors

Published: Aug. 11, 2020, 4:05 p.m.
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Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identifies disease-relevant transcripts containing G-rich motifs.

Published: Aug. 11, 2020, 4:05 p.m.
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KinPred: A unified approach and resource for human kinase-substrate predictions

Published: Aug. 10, 2020, 11:01 p.m.
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The secret of VDAC isoforms is in their gene regulation? Characterization of human VDAC genes expression profile, promoter activity, and transcriptional regulators.

Published: Aug. 10, 2020, 11:01 p.m.
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The inner membrane protein YhdP modulates the rate of anterograde phospholipid flow in Escherichia coli

Published: Aug. 10, 2020, 11:01 p.m.
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Genome-wide analysis of DNA replication and DNA double strand breaks by TrAEL-seq

Published: Aug. 10, 2020, 12:02 p.m.
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A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins

Published: Aug. 10, 2020, 12:02 p.m.
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The PNUTS-PP1 axis regulates endothelial aging and barrier function via SEMA3B suppression

Published: Aug. 10, 2020, 12:02 p.m.
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Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA.

Published: Aug. 10, 2020, 12:01 p.m.
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Sialylation and fucosylation changes of cytidine monophosphate-Nacetylneuraminic acid hydroxylase (CMAH) and glycoprotein, alpha1,3-galactosyltransferase(GGTA1) knockout pig erythrocyte membranes

Published: Aug. 7, 2020, 12:08 a.m.
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Plumbagin and oridonin reveal new CRM1 binding sites and NES-binding groove features

Published: Aug. 6, 2020, 6:03 p.m.
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The axonal sorting activity of pseudorabies virus Us9 protein depends on the state of neuronal maturation

Published: Aug. 6, 2020, 8:03 a.m.
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The human Origin Recognition Complex is essential for pre-RC assembly, mitosis and maintenance of nuclear structure.

Published: Aug. 6, 2020, 7:04 a.m.
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Prime editing primarily induces undesired outcomes in mice

Published: Aug. 6, 2020, 7:04 a.m.
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The human PDZome 2.0: characterization of a new resource to test for PDZ interactions by Yeast Two-Hybrid

Published: Aug. 6, 2020, 7:04 a.m.
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Chromosomal instability by mutations in a novel specificity factor of the minor spliceosome

Published: Aug. 6, 2020, 7:04 a.m.
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FlyORF-TaDa allows rapid generation of new lines for in vivo cell-type specific profiling of protein-DNA interactions in Drosophila melanogaster

Published: Aug. 6, 2020, 6:02 a.m.
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Development and characterization of infectious clones of two strains of Usutu virus

Published: Aug. 6, 2020, 2:03 a.m.
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Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

Published: Aug. 6, 2020, 1:03 a.m.
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Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

Published: Aug. 5, 2020, 11:03 p.m.
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Gut microbiome composition predicts summer core range size in a generalist and specialist ungulate

Published: Aug. 5, 2020, 10:03 p.m.
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Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation

Published: Aug. 5, 2020, 3:01 p.m.
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A unique neurogenomic state emerges after aggressive confrontations in males of the fish Betta splendens

Published: Aug. 5, 2020, 7:03 a.m.
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TuMV triggers stomatal closure but reduces drought tolerance in Arabidopsis

Published: Aug. 4, 2020, 11:02 p.m.
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MiRNA expression profiling and zeatin dynamic changes in a new model system of in vivo indirect regeneration of tomato

Published: Aug. 4, 2020, 10:02 a.m.
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The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans

Published: Aug. 4, 2020, 10:02 a.m.
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Using a simple cellular assay to map NES motifs in cancer-related proteins, gain insight into CRM1-mediated NES export, and search for NES-harbouring micropeptides

Published: Aug. 4, 2020, 5:02 a.m.
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Listed in: Science

SCV-2000bp: a primer panel for SARS-CoV-2 full-genome sequencing

Published: Aug. 4, 2020, 4:01 a.m.
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Mitotic activity shapes stage-specific histone modification profiles during Xenopus embryogenesis

Published: Aug. 4, 2020, 1:02 a.m.
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Cytidine monophosphate N-acetylneuraminic acid synthetase and solute carrier family 35 member A1 are required for reovirus binding and infection

Published: Aug. 4, 2020, 12:02 a.m.
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Listed in: Science

Sex identification in embryos and adults of Darwins finches

Published: Aug. 3, 2020, 8:03 a.m.
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A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival probability of tuberculous meningitis patients treated with adjunctive dexamethasone

Published: Aug. 3, 2020, 7:03 a.m.
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Listed in: Science

Mutational Survivorship Bias: The case of PNKP

Published: Aug. 3, 2020, 7:03 a.m.
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NAD modulates DNA methylation and cell differentiation

Published: Aug. 2, 2020, 1:02 p.m.
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The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis

Published: Aug. 2, 2020, 1:02 p.m.
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Subgenomic satellite particle generation in recombinant AAV vectors results from DNA lesionbreakage and non-homologous end joining

Published: Aug. 2, 2020, 7:03 a.m.
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Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease

Published: July 31, 2020, 10:28 p.m.
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Repeated evolution of inactive pseudonucleases in a fungal branch of the Dis3RNase II family of nucleases

Published: July 31, 2020, 10:28 p.m.
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The final step of 40S ribosomal subunit maturation is controlled by a dual key lock

Published: July 31, 2020, 8:02 p.m.
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Multiplex-GAM: genome-wide identification of chromatin contacts yields insights not captured by Hi-C

Published: July 31, 2020, 5:03 a.m.
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A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infection

Published: July 31, 2020, 5:03 a.m.
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SILAC proteomics implicates the ubiquitin conjugating enzyme UBE2D in SOCS1-mediated downmodulation of the MET receptor in hepatocytes

Published: July 31, 2020, 4:02 a.m.
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Nanopore sequencing reveals full-length Tropomyosin 1 isoforms and their regulation by RNA binding proteins during rat heart development

Published: July 30, 2020, 11:02 p.m.
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Genetic Code Evolution Reconstructed with Aligned Metrics

Published: July 30, 2020, 6:02 p.m.
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SCFCdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosis

Published: July 30, 2020, 4:02 p.m.
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Read counts from environmental DNA (eDNA) metabarcoding reflect fish abundance and biomass in drained ponds

Published: July 30, 2020, 9:03 a.m.
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Helicase-Like Functions in Phosphate Loop Containing Beta-Alpha Polypeptides

Published: July 30, 2020, 9:02 a.m.
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Epigenetic suppression of SLFN11 in germinal center B cells in the process of the dynamic expression change during B-cell development

Published: July 30, 2020, 8:02 a.m.
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Light induced changes in starry flounder (Platichthys stellatus) opsin expression and its influence on vision estimated from a camouflage-based behavioural assay.

Published: July 30, 2020, 8:02 a.m.
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Base-edited CAR T Cells for combinational therapy against T cell malignancies

Published: July 30, 2020, 6:02 a.m.
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Overexpression of key sterol pathway enzymes in two model marine diatoms alters sterol profiles in Phaeodactylum tricornutum

Published: July 30, 2020, 6:02 a.m.
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A dynamic regulatory interface on SARS-CoV-2 RNA polymerase

Published: July 30, 2020, 5:02 a.m.
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The ciliary protein IFT88 controls post-natal cartilage thickness and influences development of osteoarthritis.

Published: July 29, 2020, 7:02 a.m.
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Molecular detection of Leishmania donovani, Leishmania major, and Trypanosoma spp. in Sergentomyia squamipleuris sandflies from a visceral leishmaniasis focus in Merti sub-County, eastern Kenya

Published: July 29, 2020, 6:03 a.m.
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Listed in: Science

APOBEC2 binds Chromatin and Represses Transcription during Myoblast Differentiation

Published: July 29, 2020, 6:02 a.m.
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Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation

Published: July 29, 2020, 6:02 a.m.
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Structures of the germline-specific Deadhead and Thioredoxin T proteins from Drosophila melanogaster reveal unique features among Thioredoxins

Published: July 29, 2020, 6:02 a.m.
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Exosomes are predominantly loaded with mRNA transcript encoding cytoplasmic proteins and exclude mRNA transcript encoding nuclear proteins

Published: July 29, 2020, 6:02 a.m.
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Optimisation and comparison of orthogonal methods for separation and characterisation of extracellular vesicles to investigate how representative infant milk formula is of milk

Published: July 29, 2020, 1:06 a.m.
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Benchmarking full-length transcript single cell mRNA sequencing protocols

Published: July 29, 2020, 1:06 a.m.
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MSK phosphorylation of H3S28 is required for immediate early gene induction and cardiac hypertrophy

Published: July 29, 2020, 1:06 a.m.
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Heparin as an Anti-Inflammatory Agent

Published: July 29, 2020, 1:06 a.m.
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Substrate-induced clustering activates Trim-Away of pathogens and proteins

Published: July 29, 2020, 1:06 a.m.
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Synaptotagmins Maintain Diacylglycerol Homeostasis at Endoplasmic Reticulum-Plasma Membrane Contact Sites during Abiotic Stress

Published: July 29, 2020, 1:06 a.m.
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Atomistic Mechanism of Force Generation, Translocation, and Coordination in a Viral Genome Packaging Motor

Published: July 28, 2020, 10:12 p.m.
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Natural Antisense Transcript of Period2, Per2AS, regulates the amplitude of the mouse circadian clock

Published: July 28, 2020, 6:02 a.m.
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Antibody Signal peptides and essential amino acid counts on recombinant antibody production

Published: July 28, 2020, 12:03 a.m.
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Species detection within the Echinococcus granulosus sensu lato complex by novel probe-based Real-Time PCRs

Published: July 27, 2020, 8:05 p.m.
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Structural and Genetic Determinants of Convergence in the Drosophila tRNA Structure-Function Map

Published: July 27, 2020, 8:05 p.m.
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A genome-wide CRISPRCas phenotypic screen formodulators of DUX4 cytotoxicity reveals screen complications

Published: July 27, 2020, 7:01 a.m.
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Antiviral effects of miRNAs in extracellular vesicles against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mutations in SARS-CoV-2 RNA virus

Published: July 27, 2020, 5:01 a.m.
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Molecular mechanisms of Cardiac Injury associated with myocardial SARS-CoV-2 infection

Published: July 27, 2020, 5:01 a.m.
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Effects of individual base-pairs on in vivo target search and destruction kinetics of small RNA

Published: July 26, 2020, 8:05 p.m.
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Long non-coding RNA regulation of spermatogenesis and endosomal processes via the spectrin cytoskeleton in Drosophila

Published: July 26, 2020, 8:05 p.m.
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Rpb4 and Puf3 imprint and post-transcriptionally control the stability of a common set of mRNAs in yeast

Published: July 25, 2020, 8:05 p.m.
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Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXODAF-16-induced longevity

Published: July 25, 2020, 8:02 p.m.
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Caloric restriction increases levels of taurine in the intestine and stimulates taurine uptake by conjugation to glutathione

Published: July 24, 2020, 8:03 p.m.
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Spectrum of pathogenic variants and multiple founder effects in amelogenesis imperfecta associated with MMP20

Published: July 24, 2020, 8:03 p.m.
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Synergid calcium ion oscillations define a new feature of pollen tube reception critical for blocking interspecific hybridization

Published: July 24, 2020, 8:03 p.m.
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Expression of the type III secretion system genes in epiphytic Erwinia amylovora cells on apple stigmas benefits endophytic infection at the hypanthium

Published: July 24, 2020, 8:03 p.m.
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Metabarcoding reveals different zooplankton communities in northern and southern areas of the North Sea

Published: July 24, 2020, 8:03 p.m.
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Identification and characterisation of the gene encoding an amastine-like surface protein (ALSP) in the Leishmania donovani genome: a putative anti-leishmanial drug target

Published: July 24, 2020, 8:03 p.m.
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Activation of pancreatic B-cell genes by multiplex epigenetic CRISPR-editing

Published: July 24, 2020, 8:02 p.m.
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Litter expansion alters metabolic homeostasis in a sexually divergent manner

Published: July 23, 2020, 8:03 p.m.
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A dual prokaryotic (E. coli) expression system (pdMAX)

Published: July 23, 2020, 8:03 p.m.
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Ancient DNA of Rickettsia felis and Toxoplasma gondii implicated in the death of a hunter-gatherer boy from South Africa, 2,000 years ago

Published: July 23, 2020, 8:03 p.m.
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Listed in: Science