TWiV 986: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin\xa0discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, serological response to vaccination in post-acute sequelae of COVID, sex differences in cardiovascular complications and mortality in hospital patients with COVID-19, association of COVID-19 vaccination with risk for incident diabetes after COVID-19, postacute sequelae of SARS-CoV-2 in university setting, the CDC\u2019s long-Covid deception, and podcast companies, once walking on air, feel the strain of gravity.
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Links for this episode- RSV prefusion\xa0F protein vaccine\xa0in older adults (NEJM)
- Efficacy and safety\xa0of an Ad26.RSV.preF\u2013RSV preF protein vaccine (NEJM)
- Health care\xa0vaccine mandate\xa0remains as some push for an end (AP)
- Past SARS-CoV-2 infection protection against\xa0re-infection\xa0(The Lancet)
- A third vaccine dose\xa0equalizes the levels of effectiveness and immunogenicity of COVID-19 vaccine regimens (medRxiv)
- Sotrovimab retains activity against\xa0SARS-CoV-2 Omicron variant\xa0in primate model (bioRxiv)
- Effect of\xa0higher-dose Ivermectin\xa0for 6 days vs placebo in patients with COVID-19 (JAMA)
- Viral burden rebound in patients with COVID-19 receiving\xa0oral antivirals\xa0(The Lancet)
- Serological\xa0response to vaccination in post-acute sequelae of COVID (BMC)
- Sex differences in\xa0cardiovascular complications and mortality\xa0in patients with COVID-19 (BMI)
- Association\xa0of COVID-19 vaccination with risk for incident diabetes after COVID-19 (JAMA)
- Postacute sequelae of\xa0SARS-CoV-2\xa0in university setting (CDC)
- The CDC\u2019s Long-Covid\xa0deception\xa0(WSJ)
- Podcast companies, once walking on air, feel the strain of gravity (NYT)
- Contribute to our\xa0ASTMH fundraiser at PWB
- Dr. Griffin\u2019s treatment guide (pdf)
- Letters read\xa0on TWiV 986
- Don\u2019t crush Paxlovid (pdf)
- Timestamps by\xa0Jolene. Thanks!
Intro music is by\xa0Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv