TWiV 972: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin\xa0discusses\xa0the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave,\xa0virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants,\xa0comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans,\xa0time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir,\xa0COVID drug Paxlovid was hailed as a game-changer, what happened?,\xa0the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice,\xa0SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID \u2014 even with a mild case.
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Links for this episode- Infectiousness\xa0of breakthrough infections & reinfections during Omicron wave (Nature)
- Virological characteristics of the SARS-CoV-2\xa0XBB variant\xa0(bioRxiv)
- Antibody evasion\xa0properties of BQ and XBB subvariants (Cell)
- Comparative effectiveness of third doses of\xa0mRNA vaccines\xa0in US veterans (Nature)
- Time to negative\xa0PCR conversion among high-risk patients treated by Sotrovimab or Nirmatrelvir (CMI)
- Paxlovid patient eligbiliity\xa0screening checklist (FDA)
- COVID drug Paxlovid was hailed as a game-changer.\xa0What happened?\xa0(Nature)
- Fc-effector function of\xa0COVID-19 convalescent plasma\xa0contributes to treatment efficacy (Cell)
- SARS-CoV-2\xa0infection and persistence\xa0in the human body and brain at autopsy (Nature)
- Long-term\xa0cardiovascular outcomes of COVID-19 (Nature)
- Heart-disease risk soars after\xa0COVID\xa0(Nature)
- Contribute to our\xa0MicrobeTV fundraiser at PWB
- Dr. Griffin\u2019s treatment guide (pdf)
- Letters read\xa0on TWiV 972
- Timestamps by Jolene. Thanks!
Intro music is by\xa0Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv