TWiV 860: Evading a Toll on the road to RNA vaccines
TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines.
Hosts:\xa0Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episode- Vaccine Town Hall (ASV)
- Columbia University BSL-3 Manager position
- RNA modifications suppress innate recognition (Immunity)
- Critical contribution of pseudouridine (Front Cell Dev Biol)
- Rich Condit reminisces (YouTube)
- Letters read on TWiV 860
- Timestamps by Jolene. Thanks!
Dickson - NASA Research Launches a New Generation of Indoor Farming
Kathy -How Pfizer scientists transformed an old drug lead into a COVID-19 antiviral
Rich - Fermi paradox
Vincent - Racism not Race by Joe Graves
Jay \u2013 Restoration of Ave Maria
John \u2013 Pandemic humor
Intro music is by\xa0Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv