TWiV 830: A culture of resistance
TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection.
Hosts:\xa0Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Download\xa0TWiV 830 (67 MB .mp3, 112 min)
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Links for this episode- Spike protein inhibition of V(D)J recombination in vitro (Viruses)
- Evolutionary predictability of SARS-CoV-2 (PLoS Path)
- Letters read on TWiV 830
- Timestamps by Jolene. Thanks!
Kathy \u2013 When do we get back to normal? Maybe now.
Rich \u2013 The Covid-19 Pandemic
Alan \u2013 Yaupon Brothers American tea
Vincent \u2013 Cracking the genetic code (and Niremberg\u2019s account)
Justin \u2013 Partisan vaccination
Lisa \u2013 The Red Flag
Intro music is by\xa0Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv