TWiV 751: Sputnik spat and furin in ferrets
TWiV examines the claim by Brazil\u2019s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.
Hosts:\xa0Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episode- ASV vaccine town halls
- Brazil rejects Gamaleya vaccine (Sci Transl Med)
- Russian vaccine behavior (Sci Transl Med)
- Is Gamaleya vaccine safe? (Science)
- Furin cleavage site in replication and transmission (Nat Micro)
- Furin site loss attenuates pathogenesis (Nature)
- Timestamps by Jolene. Thanks!
Rich \u2013 The diversity and function of sourdough starter microbiomes; Dunn Lab Wild Sourdough Project
Kathy \u2013 ISS, Crew Dragon, and the sun\xa0 Doubly warped world of binary black holes
Vincent \u2013 Mr. Labman
Joy \u2013 Abandoned America: Matthew Christopher\u2019s Autopsy of the American Dream
Intro music is by\xa0Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv