TWiV 740: Complementation will get you everywhere
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.
Hosts:\xa0Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode- NIDO 2021 Symposium
- ASV hosts free COVID-19 Vaccine Education Town Halls (register here)
- Research position in Spindler laboratory
- Attenuation of poliovirus by codon deoptimization (Science)
- Rescue of codon-deoptimized RSV by large deletions (PNAS)
- Letters read on TWiV 740
- Timestamps by Jolene. Thanks!
Dickson \u2013 Let us now praise tiny ants
Brianne \u2013 Small-school science
Rich \u2013 Smallpox \u2018virus squads\u2019 and the mandatory vaccinations upheld by the Supreme Court
Kathy \u2013 The Transcontinental Burrito Tunnel
Vincent \u2013 Glass music by Robert Tiso
Intro music is by\xa0Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv